Chronicles Of Pharmacy - free ebook by A. C. Wootton

CHRONICLES OF PHARMACY

BY A. C. WOOTTON VOL. I MACMILLAN AND CO., LIMITED ST. MARTIN’S STREET, LONDON 1910 Richard Clay and Sons, Limited, BREAD STREET HILL, E.C., AND BUNGAY, SUFFOLK....

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PREFACE

Pharmacy, or the art of selecting, extracting, preparing, and compounding medicines from vegetable, animal, and mineral substances, is an acquirement which must have been almost as ancient as man himself on the earth. In experimenting with fruits, seeds, leaves, or roots with a view to the discovery of varieties of food, our remote ancestors would occasionally find some of these, which, though not tempting to the palate, possessed this or that property the value of which would soon come to be re

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PUBLISHERS’ NOTE

As the author unhappily died while his book was still in the printer’s hands, his friend, Mr. Peter MacEwan, editor of The Chemist and Druggist , has been good enough to revise the proofs for press. VOL. I...

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ERRATA VOL. I

Page 101. Tenth line from top, for Mesué read Mesuë. „ 211. Sixth line from bottom, reference should be : Vol. II., 63. „ 217. Eighth line from top, reference should be : Vol. II., 182. „ 224. Top line, reference should be : Vol. II., 37. „ 337. Second line from top, additional reference : Vol. II., 179. „ 419. Ninth line from top, for Panchymagogum read Panchymagogon. CHRONICLES OF PHARMACY “Deorum immortalium inventioni consecrata est Ars Medica.”— Cicero , Tusculan. Quaest. , Lib. 3

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THE INVENTORS OF MEDICINE

Medicine and Magic consequently became intimately associated, and useful facts, superstitious practices, and conscious and unconscious deceptions, became blended into a mosaic which formed a fixed and reverenced System of Medicine. Again the supernatural powers were called in and the credit of the revelation of this Art, that is its total fabric, was attributed either to a divine being who had brought it from above, or to some gifted and inspired creature, who in consequence had been admitted in

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THE PATRON SAINTS OF PHARMACY.

Cosmas and Damien, who are regarded as the patron saints of pharmacy in many Catholic countries, were two brothers, Arabs by birth, but who lived in the city of Egea, in Cilicia, where they practised medicine gratuitously. Overtaken by the Diocletian persecution in the fourth century, they were arrested and confessed their faith. Being condemned to be drowned, it is related that an angel severed their bonds so that they could gain the shore. They were then ordered to be burnt, but the fire attac

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FABLES OF PLANT MEDICINES.

The Mandrake (Atropa Mandragora) has been exceptionally famous in medical history. Its reputation for the cure of sterility is alluded to in the story of Leah and Rachel (Genesis xxx, 14–16). It is not, however, certain that the Hebrew word “dudaim” should be translated mandrake. Various Biblical scholars have questioned this which was the Septuagint rendering. Lilies, violets, truffles, citrons, and other fruits have been suggested. In Cant., vii, 14, the same plant is described as fragrant, an

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MYTHICAL ANIMALS.

The Phœnix was largely adopted by the alchemists as their emblem, and afterwards was a frequent sign used by pharmacists. According to Herodotus this bird, which was worshipped by the Egyptians, was of about the size of an eagle, with purple and gold plumage, and a purple crest. Its eyes sparkled like stars; it lived a solitary life in the Arabian desert, and either came to Heliopolis, the city of the sun, to die and be burned in the temple of that city, or its ashes were brought there by its su

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II PHARMACY IN THE TIME OF THE PHARAOHS

“Go up into Gilead and take balm, O virgin daughter of Egypt: in vain dost thou use many medicines; there is no healing for thee.” So wrote the prophet Jeremiah (xlvi, 11), and the passage seems to suggest that Egypt in his time was famous for its medicines. Herodotus, who narrated his travels in Egypt some two or three hundred years later, conveys the same impression, and the records of the papyri which have been deciphered within the last century confirm the opinion. Whatever may have been the

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Medicines of the Jews.

The Papyrus Ebers was supposed by its discoverer to have been compiled about the time when Moses was living in Egypt, a century before the Exodus. There is no evidence in the Bible that the Jews brought with them from the land of their captivity any of the medical lore which that and other papyri not much later reveal. It is not certain that in the whole of the Bible there is any distinct reference to a medicine for internal administration. It is assumed that Rachel wanted the mandrakes which Re

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The Apothecary

is, or was, familiar to readers of the Old Testament, but in the revised translation he has partially disappeared. The earliest allusion to him occurs in Exodus xxx., 25, where the holy anointing oil is prescribed to be made “after the art of the apothecary”; and in the same chapter, v. 29, incense is similarly ordered to be made into a confection “after the art of the apothecary, tempered together.” The Revised Version gives in both cases “the art of the perfumer,” and instead of the incense be

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Pharmacy, Disgraceful.

The Greek word, pharmakeia, the original of our “pharmacy,” had a rather mixed history in its native language. It does not seem to have exactly deteriorated, as words in all languages have a habit of doing, for from the earliest times it was used concurrently to describe the preparation of medicines, and also through its association with drugs and poisons and the production of philtres, as equivalent to sorcery and witchcraft. It is in this latter sense that it is employed exclusively in the New

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DRUGS NAMED IN THE BIBLE.

is now usually identified with the exudation from the Balsamum Gileadense, known as Opobalsamum, a delicately odorous resinous substance of a dark red colour, turning yellow as it solidifies. It is not now used in modern pharmacy, except in the East. The London Pharmacopœia of 1746 authorised the substitution of expressed oil of nutmeg for it in the formula for Theriaca. Some Biblical commentators have preferred to regard mastic as the original Balm of Gilead, and others have thought that styrax

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Hippocrates.

Hippocrates was born in Cos, as far as can be ascertained, about the year 460 B.C. , and is alleged to have lived to be 99, or, as some say, 109 years of age. It is claimed that his father, Heraclides, was a direct descendant of Æsculapius, and that his mother, Phenarita, was of the family of Hercules. His father and his paternal ancestors in a long line were all priests of the Æsculapian temples, and his sons and their sons after them also practised medicine in the same surroundings. The family

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Pharmacy in the Roman Empire.

The separation of the practices of medicine, pharmacy, and surgery, which became general though never universal, was of course a gradual process. Galen expresses the opinion that Hippocrates prepared the medicines he prescribed with his own hands, or at least superintended the production of them. According to Celsus, it was in Alexandria and about the year 300 B.C. that the division of the practice of medicine into distinct branches was first noticeable. The sections he names were Dietetics, Sur

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VI ARAB PHARMACY.

In the science of medicine the Arabians have been deservedly applauded. The names of Mesua and Geber, of Razis and Avicenna, are ranked with the Grecian masters; in the city of Bagdad 860 physicians were licensed to exercise their lucrative profession; in Spain the lives of the Catholic princes were entrusted to the skill of the Saracens; and the School of Salerno, their legitimate offspring, revived in Italy and Europe the precepts of the healing art.— Gibbon : “Decline and Fall of the Roman Em

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VII FROM THE ARABS TO THE EUROPEANS

“Mediciners, like the medicines which they employ, are often useful, though the one were by birth and manners the vilest of humanity, as the others are in many cases extracted from the basest materials. Men may use the assistance of pagans and infidels in their need, and there is reason to think that one cause of their being permitted to remain on earth is that they might minister to the convenience of true Christians.”—The Archbishop of Tyre in Sir Walter Scott’s Talisman . It would require a v

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British Pharmacy in Saxon England.

The condition of medicine and pharmacy in Saxon times has been carefully portrayed in three volumes published, in 1864, under the authority of the Master of the Rolls at the expense of the Treasury. These were edited by the Rev. Oswald Cockayne, M.A., and appeared under the title of “Leechdoms, Wortcunning, and Starcraft.” Many old documents were translated and explained, and from these the ideas of medicine in these islands a thousand years ago were made manifest. Mr. Cockayne gave at length a

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Cress, Watercress (Nasturtium officinale).

1. This wort is not sown, but it is produced of itself in wylls (springs), and in brooks, also it is written that in some lands it will grow against walls. 2. In the case that a man’s hair fall off take juice of the wort which one nameth nasturtium, and by another name cress; put it on the nose; the hair shall wax (grow). 3. For sore of head, that is for scurf and for itch, take seed of this same wort and goose grease. Pound together. It draws from the head the whiteness of the scurf. 4. For sor

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Maythe (Anthemis nobilis).

For sore of eyes, let a man take ere the upgoing of the sun, the wort which is called Chamaimelon, and by another name Maythe, and when a man taketh it let him say that he will take it against white specks, and against soreness of the eyes; let him next take the ooze, and smear the eyes therewith....

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Poppy (Papaver somniferum).

1. For sore of eyes, that is what we denominate blearedness, take the ooze of this wort, which the Greeks name Makona and the Romans Papaver album, and the Engles call white poppy, or the stalk with the fruit; lay it to the eyes. 2. For sore of temples or of the head, take ooze of this same wort, pound with vinegar, and lay upon the sore; it alleviates the sore. 3. For sleeplessness, take ooze of this same wort, smear the man with it, and soon thou sendest the sleep on him. Many of the herbs nam

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The English Apothecaries.

Although the Grocers were the recognised drug dealers of this country, apothecaries who were associated in their Guild were also recognised. Some authorities name Richard Fitznigel as apothecary to Henry II before he was made Bishop of London. But this evidence cannot be trusted. The first definite allusion to an apothecary in England occurs in 1345, when Edward III granted a pension of sixpence a day for life to Coursus de Gangeland, an apothecary of London, in recognition of his services in at

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Egyptian, Jewish, and Arabic Magic.

The Egyptians, according to Celsus, believed that there were thirty-six demons or divinities in the air, to each of whom was attributed a separate part or organ of the human body. In the event of disease affecting one of these parts the priest-physician invoked the demon, calling him by his name, and requiring him in a special form of words to cure the afflicted part. Solomon was credited among many Eastern people with having discovered many of the secrets of controlling diseases by magical proc

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The Abracadabra Mystery.

Abracadabra was the most famous of the ancient charms or talismans employed in medicine. Its mystic meaning has been the subject of much ingenious investigation, but even its derivation has not been agreed upon. The first mention of the term is found in the poem “De Medicina Praecepta Saluberrima,” by Quintus Serenus Samonicus. Samonicus was a noted physician in Rome in the second and third centuries. He was a favourite with the Emperor Severus, and accompanied him in his expedition to Britain A

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Greek and Roman Magic.

Pythagoras taught that holding dill in the left hand would prevent epilepsy. Serapion of Alexandria ( B.C. 278) prescribed for epilepsy the warty excrescences on the forelegs of animals, camel’s brain and gall, rennet of seal, dung of crocodile, blood of turtle, and other animal products. Pliny alludes to a tradition, that a root of autumnal nettle would cure a tertian fever, provided that when it is dug the patient’s name and his parent’s names are pronounced aloud; that the longest tooth of a

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English Folk-Lore Superstitions.

It would be as tedious as it would be useless to relate at any length the multitude of silly superstitions which make up the medicinal folk-lore of this and other countries. Methods of curing warts, toothache, ague, worms, and other common complaints are familiar to everyone. The idea that toothache is caused by tiny worms which can be expelled by henbane, is very ancient and still exists. A process from one of the Anglo-Saxon Leechdoms converted into modern English by the Rev. Oswald Cockayne m

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Transferring Diseases.

It was widely believed that disease could be transferred by means of certain silly formalities. This was a very ancient notion. Pliny explains how pains in the stomach could be transferred to a duck or a puppy. A prescription of about two hundred years ago for the cure of convulsions was to take parings of the sick man’s nails, some hair from his eyebrows, and a halfpenny, and wrap them all in a clout which had been round his head. This package must be laid in a gateway where four lanes meet, an

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Witches’ Powers.

The powers of witches were extensive but at the same time curiously restricted. When Agnes Simpson was tried in Scotland in 1590 she confessed that to compass the death of James VI she had hung up a black toad for nine days and caught the juice which dropped from it. If she could have obtained a piece of linen which the king had worn she could have killed him by applying to it some of this venom, which would have caused him such pain as if he had lain on sharp thorns or needles. Another means th

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The Universal Tendency.

It would merely try the patience of the reader to enumerate even a tithe of the absurd things which have been and are being used by people, civilised and savage, as charms, talismans, and amulets. The teraphim which Rachel stole from her father Laban, the magic knots of the Chaldeans, the gold and stone ornaments of the Egyptians, which they not only wore themselves but often attached to their mummies—a multitude of these going back as far as the flint amulets of the predynastic period, are to b

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Elements and Phlogiston.

The ancient idea that earth, air, fire, and water were the elements of Nature was held by chemists in the 18th century. Empedocles appears to have been the author of this theory, which was adopted by Aristotle. Some speculative philosophers, however, taught that all of these were derived from one original first principle; some held that this was water, some earth, some fire, and others air. Paracelsus, who does not seem to have objected to this idea, contributed another fantastic one to accompan

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Humours and Degrees.

The doctrine of the “humours,” or humoral pathology, as it is generally termed, is usually traced to Hippocrates. It is set forth in his book on the Nature of Man, which Galen regarded as a genuine treatise of the Physician of Cos, but which other critics have supposed to have been written by one or more of his disciples or successors. At any rate, it is believed to represent his views. Plato elaborated the theory, and Galen gave it dogmatic form. The human body was composed not exactly of the f

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The Rosicrucians.

It has never been pretended, so far as I am aware, that the Rosicrucian mystics of the middle ages did anything for the advancement of pharmacy. They are only mentioned here because they claimed the power of curing disease, and also because it happens that the fiction which created the legends concerning them was almost contemporaneous with the not unsimilar one (if the latter be a fiction) which made a historical figure of Basil Valentine. Between 1614 and 1616 three works were published profes

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The Doctrine of Signatures

was at least intelligible. It associated itself, too, with the pious utterances so frequent among the mediæval teachers and practitioners of medicine. The theory was that the Creator in providing herbs for the service of man had stamped on them, at least in many instances, an indication of their special remedial value. The adoption of ginseng root by the Chinese as a remedy for impotence, and of mandrake by the Hebrews and Greeks in the treatment of sterility, those roots often resembling the ma

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Metals and Precious Stones.

It will be noticed that parts of animals are credited in the examples just quoted with remedial properties. This was a natural extension of the doctrine. Metals, too, were credited with medicinal virtues corresponding with their names or with the deities and planets with which they had been so long associated. The sun ruled the heart, gold was the sun’s metal, therefore gold was especially a cordial. The moon, silver, and the head were similarly associated. Iron was a tonic because Mars was stro

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Sympathetic Remedies.

Among the strange theories which have found acceptance in medical history, mainly it would seem by reason of their utter baselessness and absurdity, none is more unaccountable than the belief in the so-called sympathetic remedies. There is abundant material for a long chapter on this particular manifestation of faith in the impossible, but a few prominent instances of the remarkable method of treatment comprised in the designation will suffice to prove that it was seriously adopted by men capabl

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Animal Magnetism.

The first allusion to the application of the magnet as a cure for disease is found in the works of Aetius, who wrote in the early part of the sixth century. He mentions that holding a magnet in the hand is said to give relief in gout. He does not profess to have tested this treatment himself. Writers of the fifteenth and sixteenth centuries recommend it strongly for toothache, headache, convulsions, and nerve disorders. About the end of the seventeenth century magnetic tooth-picks and earpicks w

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The Treatment of Itch.

The history of the treatment of itch is such a curious instance of the blind acceptance of authority through many centuries, in the course of which the true explanation lay close at hand, that it is worth narrating briefly. It is stated in some histories that the disease was known to the Chinese some thousands of years ago, and the name they gave it, Tchong-kiai, which means pustules formed by a worm, indicates that at least when that term was adopted they had some acquaintance with the characte

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Dioscorides.

It has been a subject of lively dispute whether Dioscorides lived before or after Pliny. It seems certain that one of these authors copied from the other on particular matters, and in neither case is credit given. Pliny was born A.D. 23 and died A.D. 79, and would therefore have lived under the Emperors Tiberius, Caligula, Claudius, Nero, Galba, Otho, Vitellius, and Vespasian. Suidas, the historian, who probably wrote in the tenth century, dates Dioscorides as contemporary with Antony and Cleopa

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Galen.

No writer of either ancient or modern times can compare with Claudius Galenus probably in the abundance of his output, but certainly in the influence he exercised over the generations that followed him. For fifteen hundred years the doctrines he formulated, the compound medicines he either introduced or endorsed, and the treatments he recommended commanded almost universal submission among medical practitioners. In Dr. Monk’s Roll of the College of Physicians, mention is made of a Dr. Geynes who

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Oribasius.

Oribasius, like Galen, was a native of Pergamos, and was physician to and friend of the Emperor Julian. He is noted for having compiled seventy-two books in which he collected all the medical science of preceding writers. This was undertaken at the instance of Julian. Only seventeen of these books have been preserved to modern times. Oribasius adds to his compilation many original observations of his own, and in these often shows remarkable good sense. He was the originator of the necklace metho

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Aetius.

Aetius, who lived either in the fifth or sixth century, was also a compiler, but he was besides a great authority on plasters, which he discusses and describes at enormous length. He was a Christian, and gives formulas of words to be said when making medicinal compounds, such as “O God of Abraham, of Isaac, and of Jacob, give to this remedy the virtues necessary for it.” In the works of Aetius, mention is made of several nostrums famous in his time for which fabulous prices were charged. The Col

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Alexander of Tralles.

This writer, who acquired considerable celebrity as a medical authority, lived a little later than Aetius, towards the end of the sixth century. He was a native of Tralles, in Lydia, and is much esteemed by the principal medical historians, Sprengel, Leclerc, Freind, and others who have studied his writings. Especially notable is his independence of opinion; he does not hesitate occasionally to criticise even Galen. He impresses strongly on his readers the danger of becoming bound to a particula

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Mesuë and Serapion.

These names are often met with in old medical and pharmaceutical books, and there is an “elder” and a “younger” of each of them, so that it may be desirable to explain who they all were. The elder and the younger of each are sometimes confused. Serapion the Elder, or Serapion of Alexandria, as he is more frequently named in medical history, lived in the Egyptian city about 200 B.C. , and was the recognised leader of the sect of the Empirics in medicine. He is credited with the formula that medic

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Nicolas Myrepsus.

For several centuries before the era of modern pharmacopœias the Antidotary of Nicolas Myrepsus was the standard formulary, and from this the early dispensatories were largely compiled. This Nicolas, who was not the Nicolas Praepositus of Salerno, is sometimes named Nicolas Alexandrinus. He appears to have been a practising physician at Constantinople, and as he bore the title of Actuarius, it is supposed that he was physician to the Emperor. He is believed to have lived in the thirteenth centur

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Raymond Lully.

The life of Raymond Lully is so romantic that it is worth telling, though it only touches pharmaceutical history occasionally. Born at Palma, in the island of Majorca, in 1235, in a good position of life, he married at the age of twenty-two, and had two sons and a daughter. But home life was not what he desired, and he continued to live the life of a gallant, serenading young girls, writing verses to them, and giving balls and banquets, to the serious derangement of his fortune. Ultimately he co

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Frascator.

Hieronymo Frascatoro, generally known as Jerome Frascator, was a physician and poet of high repute in the early part of the sixteenth century. Frascator was born at Verona in 1483 and died near that city in 1553. As a physician he aided the Pope, Paul III, to get the Council of Trent removed from Germany to Italy by alarming the delegates into believing that they were in imminent danger of an epidemic. They therefore adjourned to Bologna. Frascator especially studied infectious diseases, and his

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Basil Valentine.

The name and works of Basil Valentine are inseparably associated with the medical use of antimony. His “Currus Triumphalis Antimonii” (the Triumphal Chariot of Antimony) is stated in all text-books to have been the earliest description of the virtues of this important remedy, and of the forms in which it might be prescribed. And very wonderful indeed is the chemical knowledge displayed in this and other of Valentine’s writings. Basil Valentine. (From the Collection of Etchings in the Royal Galle

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Paracelsus: His Career.

No one man in history exercised such a revolutionary influence on medicine and pharmacy as the erratic genius Philipus Aureolus Theophrastus Bombast von Hohenheim. The name Paracelsus is believed to have been coined by himself, probably with the intention of somewhat Latinising his patronymic, von Hohenheim, and also perhaps as claiming to rank with the famous Roman physician and medical writer, Celsus. The family of Bombast was an old and honourable one from Württemberg, but the father of the f

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His Character.

Such details of the personality of Paracelsus as have come down to us were written by his enemies. Erastus, a theologian as well as a physician, who may have met Paracelsus, and who fiercely attacked his system, depreciates him on hearsay. But Operinus, a disciple who had such reverence for him that when Paracelsus left Basel, he accompanied him and was with him night and day for two years, wrote a letter about him after his death to which it is impossible not to attach great importance. In this

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His Mysticism.

The mystic views of Paracelsus, or those attributed to him, are curious rather than useful. He seemed to have had as much capacity for belief as he had disbelief in other philosophers’ speculations. He believed in gnomes in the interior of the earth, undines in the seas, sylphs in the air, and salamanders in fire. These were the Elementals, beings composed of soul-substance, but not necessarily influencing our lives. The Elementals know only the mysteries of the particular element in which they

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His Chemical and Pharmaceutical Innovations.

These fantastic notions permeate all the medical treatises of Paracelsus. But every now and then there are indications of keen insight which go some way towards explaining his success as a physician; for it cannot be doubted that he did effect many remarkable cures. His European fame was not won by mere boasting. His treatise, De Morbis ex Tartare oriundus , is admittedly full of sound sense. Some of his chemical observations are startling for their anticipations of later discoveries. If there w

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His Pharmacy.

The composition of Paracelsus’s laudanum, the name of which he no doubt invented, has never been satisfactorily ascertained. Paracelsus himself made a great secret of it, and probably used the term for several medicines. It was generally, at least, a preparation of opium, sometimes opium itself. He is believed to have carried opium in the pommel of his sword, and this he called the “stone of immortality.” Next to opium he believed in mercury, and was largely influential in popularising this meta

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Nicholas Culpepper.

This well-known writer, whose “Herbal” has been familiar to many past generations as a family medicine book, deserves a place among our Masters in Pharmacy for the freedom, and occasional acuteness with which he criticised the first and second editions of the London Pharmacopœia. One specimen of his sarcastic style must suffice. The official formula for Mel Helleboratum was to infuse 3 lbs. of white hellebore in 14 lbs. of water for three days; then boil it to half its bulk; strain; add 3 lbs. o

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Turquet de Mayerne.

Sir Theodore Turquet de Mayerne, Baron Aulbone of France, was born at Geneva in 1573, of a Calvinistic family and studied for the medical profession first at Heidelberg and afterwards at Montpellier. Moving to Paris he acquired popularity as a lecturer on anatomy to surgeons, and on pharmacy to apothecaries. His inclination towards chemical remedies brought him to the notice of Rivierus, the first physician to Henri IV, and he was appointed one of the king’s physicians. But his medical heterodox

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Van Helmont.

Jean Baptiste Van Helmont, born at Brussels in 1577, and died at Vilvorde near that city in 1644, was an erratic genius whose writings and experiments sometimes astonish us by their lucidity and insight, and again baffle us by their mysticism and puerility. Van Helmont was of aristocratic Flemish descent, and possessed some wealth. He was a voracious student and a brilliant lecturer. At the University of Louvain, however, where he spent several years, he refused to take any degree because he bel

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Glauber

John Rudolph Glauber, who was born at Carlstadt, in Germany, in 1603, contributed largely to pharmaceutical knowledge, and deserves to be remembered by his many investigations, and perhaps even more for the clear common sense which he brought to bear on his chemical work. For though he retained a confident belief in the dreams of alchemy, he does not appear to have let that belief interfere with his practical labour; and some of his processes were so well devised that they have hardly been alter

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Goulard.

Thomas Goulard was a surgeon of Montpellier with rather more than a local reputation. He was counsellor to the king, perpetual mayor of the town of Alet, lecturer and demonstrator royal in surgery, demonstrator royal of anatomy in the College of Physicians, fellow of the Royal Academies of Sciences in Montpellier, Toulouse, Lyons, and Nancy, pensioner of the king and of the province of Languedoc for lithotomy, and surgeon to the Military Hospital of Montpellier. His treatise on “The Extract of S

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Scheele.

Karl Wilhelm Scheele is the most famous of pharmacists, and has few equals in scientific history. He was the seventh child of a merchant at Stralsund, then in the possession of Sweden, and was born on December 9th, 1742. He had a fair education and at school was diligent and apt in acquiring knowledge. If he was born with a gift, if his genius was anything more than an immense capacity for taking pains, this aptness was the faculty which distinguished Scheele from other men. He made thousands of

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A Pharmaceutical Pantheon.

The School of Pharmacy of Paris, built in 1880, honours a number of pharmacists of historic fame by placing a series of medallions on the façade of the building, as well as statues of two specially eminent representatives of the profession in the Court of Honour. These two are Vauquelin and Parmentier. École de Pharmacie, Paris. (From photo sold at School.) Louis Nicolas Vauquelin was director of the School from its foundation in 1803 until his death in 1829. He also held professorships at the S

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Classical Legends.

Chin-Nong, Emperor of China, who died 2699 B.C. , is reckoned to have been the founder of pharmacy in the Far East. He studied plants and composed a Herbal used to this day. It is related of him that he discovered seventy poisonous plants and an equal number of antidotes to them. He describes how to make extracts and decoctions, what they are good for, and had some notions of analysis. Chin-Nong was the second of the nine sovereigns who preceded the establishment of the Chinese dynasties. To him

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Mithridatium.

Mithridates VI, commonly called “the Great,” King of Pontus in Asia Minor, was born 134 B.C. , and succeeded his father on the throne at the age of twelve. Next to Hannibal he was the most troublesome foe the Roman Republic had to deal with. His several wars with that power occupied twenty-six years of his life. Sylla, Lucullus, and Pompey, in succession, led Roman armies against him, and gained battles again and again, but he was only at last completely conquered by the last-named general after

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A Pharmaceutical Pope.

Peter of Spain, a native of Lisbon, was a physician who became Pope under the title of John XXI. He died in 1277. He wrote a treatise on medicine, or rather made a collection of formulas, including most of the absurd ones then current and adding a few of his own. One was to carry about a parchment on which were written the names of Gaspard, Balthasar, and Melchior, the three wise men of the East, as a sure preservative from epilepsy. Another was a method of curing a diarrhœa by filling a human b

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Henry VIII (of England)

was fond of dabbling with medicine. In Brewer’s history of his reign, referring to the years 1516–18, we are told:— “The amusements of court were diversified by hunting and out-door sports in the morning; in the afternoon by Memo’s music, by the consecration and distribution of cramp rings, or the invention of plasters and compounding of medicines, an occupation in which the King took unusual pleasure.” In the British Museum among the Sloane MSS. there is one numbered 1047, entitled Dr. Butt’s D

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Queen Elizabeth of England

appears to have been an amateur prescriber. Etmuller states that she sent a formula for a “cephalica-cardiac medicine” to the Holy Roman Emperor, Rudolf II, himself a dabbler in various scientific quackeries. It consisted of amber, musk, and civet, dissolved in spirit of roses. It is further on record that the English queen selected doctors and pharmacists for Ivan the Terrible of Russia. In Wadd’s Memorabilia, one of her Majesty’s quarter’s bills from her apothecary, Hugo Morgan, is quoted. It

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The Queen of Hungary’s Water.

Rosemary has at times enjoyed a high reputation among medicinal herbs. Arnold of Villa Nova affirms that he had often seen cancers, gangrenes, and fistulas, which would yield to no other medicine, dry up and become perfectly cured by frequently bathing them with a spirituous infusion of rosemary. His disciple, Raymond Lully, extracted the essential oil by distillation. The name probably assisted the fame of the plant. In the middle ages it was believed to be associated with the Virgin. It was in

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The Royal Touch.—The King’s Evil.

There are several instances in ancient history illustrating the healing virtue residing or alleged to reside in the person of a king. Pyrrhus, King of Epirus, according to Plutarch, cured colics and affections of the spleen by laying patients on their backs and passing his great toe over their bodies. Suelin relates that when the Emperor Vespasian was at Alexandria a poor blind man came to him saying that the god Serapis had revealed to him that if he, the Emperor, would touch his eyes with his

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Cramp Rings.

Faith in “cramp rings” corresponds in many respects with the reverential confidence in the royal touch as a cure for scrofula. The former, however, appears to have been of entirely English origin. Legend attributes the first cramp ring to Edward the Confessor. St. Edward on his death-bed is alleged to have given a ring from his finger to the Abbot of Westminster with the explanation that it had been brought to him not long before by a pilgrim from Jerusalem to whom it had been given by a mysteri

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The Earl of Warwick’s Powder.

The Earl of Warwick’s Powder is named in many old English, and more frequently still in foreign dispensatories and pharmacopœias, appearing generally under the title of “Pulvis Comitis de Warwick, or Pulvis Warwiciensis,” sometimes also as “Pulvis Cornacchini.” It is the original of our Pulv. Scammon Co, and was given in the P.L. 1721 in its pristine form, thus:— In the P.L. 1746 the pulvis e scammonio compositus, made from four parts of scammony and three parts of burnt hartshorn, was substitut

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Duke of Portland’s Gout Powder.

Under this title a powder had a great reputation about the middle of the eighteenth century, and well on into the nineteenth century. The powder was composed of aristolochia rotunda (birthwort root), gentian root, and the tops and leaves of germander, ground pine, and centaury, of each equal parts. One drachm was to be taken every morning, fasting, for three months, and then ½ drachm for the rest of the year. Particular directions in regard to diet were given with the formula. The compound was e

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Sir Walter Raleigh’s Great Cordial.

During his twelve years’ imprisonment in the Tower in the earlier part of the reign of James I, Sir Walter Raleigh was allowed a room in which he fitted up a laboratory, and divided his time between chemical experiments and literary labours. It was believed that Raleigh had brought with him from Guiana some wonderful curative balsam, and this opinion, combined with the knowledge that he dabbled largely with retorts and alembics in the Tower, ensured a lively public interest in his “Great Cordial

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Tar Water as a Panacea.

George Berkeley was born in 1685 in Kilkenny county, Ireland, but claimed to be of English extraction. He graduated at Trinity College, Dublin, and became a Fellow of that College. His metaphysical speculations made him famous. He was the originator of the view that the actual existence of matter was not capable of proof. Having been appointed Dean of Derry he was well provided for, but just then he became enthusiastically desirous to convert and civilise the North American Indians. With this ob

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Kings Buy Secret Remedies.

In past times it was not unusual for monarchs to purchase from the inventors of panaceas the secrets of their composition for publication for the benefit of their subjects. Several instances are mentioned in other chapters of this book. Among these may be noted Goddard’s Drops, bought by Charles II., Glauber’s Kermes Mineral or Poudre des Chartres, Talbor’s Tincture of Bark, and Helvetius’s Ipecacuanha, the secrets of which were obtained by Louis XIV for fancy prices. In Louis XIV’s reign the Fr

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Acids, Alkalies, and Salts.

Under the above title almost the entire history of chemistry might be easily comprehended. The gradual growth of definite meanings attached to these terms has been coincident with the attainment of accurate notions concerning the composition of bodies. To the ancient philosophers sour wine, acetum vinæ, or acetum as it is still called, was the only acid definitely known. When the alchemists became busy trying to extract the virtue out of all substances they produced several acids by distillation

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Alcohol.

Al-koh’l was an Arabic word indicating the sulphide of antimony so generally used by Eastern women to darken their eyebrows, eyelashes, and the eyes them selves. Similar words are found in other ancient languages. Cohal in Chaldee is related to the Hebrew kakhal used in Ezekiel, xxiii, 40, in the sense of to paint or stain. The primary meaning of alcohol therefore is a stain. Being used especially in reference to the finely levigated sulphide of antimony, the meaning was gradually extended to ot

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Alum.

Alum is a substance which considerably mystified the ancient chemists, who knew the salt but did not understand its composition. Ancient writers like Pliny and Dioscorides were acquainted with a product which the former called alumen and which is evidently the same as had been described by Dioscorides under the name of Stypteria. Pliny says there were several varieties of this mineral used in dyeing, and it is clear from his account that his alumen was sometimes sulphate of iron and sometimes a

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Ammonia.

The chemical history of ammonia commences in Egypt with Sal Ammoniac. This is mentioned by Pliny under the name of Hammoniacus sal. Dioscorides also alludes to it; but in neither case does the description given fit in satisfactorily with the product known to us. Dioscorides, for instance, states that sal ammoniac is particularly prized if it can lie easily split up into rectangular fragments. It has been conjectured that what was called sal ammoniac by the ancient writers was, at least sometimes

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Spiritus Ammoniæ Aromaticus

was first inserted in the P.L. 1721, under the title of “Spiritus Salis Volatilis Oleosus.” Cinnamon, mace, cloves, citron, sal ammoniac, and salts of tartar were distilled with spirit of wine. In 1746 the process was altered, sal ammoniac and fixed alkali being first distilled with proof spirit to yield “spiritus salis anmioniaci dulcis,” to which essential oils of lemon, nutmeg, and cloves were added, and the mixture was then re-distilled. In 1788 the spirit became spiritus ammoniæ compositus,

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Bromine.

Bromine, isolated by Balard in 1826, was named by the discoverer Muride, from Muria, brine. Its actual name was suggested by Gay Lussac from Bromos, a stench. Schultzenberger relates, on the authority of Stas, that some years before the discovery of bromine by Balard, a bottle of nearly pure bromine was sent to Liebig by a German company of manufacturers of salt, with the request that he would examine it. Somewhat carelessly the great chemist tested the product and assumed that it was chloride o

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Collodion.

Pyroxylin was discovered by Schönbein in 1847, and the next year an American medical student at Boston, Massachussets, described in the American Journal of the Medical Sciences his experiments showing the use that could be made of this substance in surgery when dissolved in ether and alcohol. By painting it on a band of leather one inch wide and attaching this to the hand, he caused the band to adhere so firmly that it could not be detached by a weight of twenty pounds....

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Epsom Salts.

The medicinal value of the Epsom springs was discovered, it is believed, towards the end of the sixteenth century, in the reign of Queen Elizabeth. According to a local tradition the particular spring which became so famous was not used for any purpose until one very dry summer, when the farmer on whose land it existed bethought him to dig the ground round about the spring, so as to make a pond for his cattle to drink from. Having done this he found that the animals would not touch the water, an

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Ether.

The action of sulphuric acid on spirit of wine is alluded to in the works of Raymond Lully in the thirteenth century, and in those attributed to Basil Valentine, by whom the product is described as “an agreeable essence and of good odour.” Valerius Cordus, in 1517, described a liquor which he called Oleum Vitrioli Dulce in his “Chemical Pharmacopœia.” This was intended to represent the Spiritus Vitrioli Antepilepticus Paracelsi. It was prepared by distilling a mixture of equal parts of sulphuric

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Spirit of Nitrous Ether.

This popular medicine has been traced back to Raymond Lully in the thirteenth century, and to Basil Valentine. But the doctor who brought it into general use was Sylvius (de la Boe) of Leyden, for whom it was sold as a lithontryptic at a very high price. It first appeared in the P.L., 1746, as Spiritus Nitri dulcis. In English this was for a long time called “dulcified spirit of nitre,” and in the form of sweet spirit of nitre still remains on our labels. In the P.L., 1788, the title was changed

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Ethiops.

Æthiops or Ethiops originally meant a negro or something black. The word is alleged to have been derived from aithein, to burn, and ops, the face, but this etymology was probably devised to fit the facts. There is no historical evidence in its favour. Most likely the word was a native African one of unknown meaning. It became a popular pharmaceutical term two or three hundred years ago, but is now almost obsolete, at least in this country. In France several mercurial preparations are still known

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Iodine

was discovered by Bernard Courtois in 1811. Courtois, who was born at Dijon in 1777, was apprenticed to a pharmacist at Auxerre named Fremy, grandfather of the noted chemist of that name, and was afterwards associated as assistant with Seguin, Thénard, and Fourcroy. He had worked with the first-named of these in the isolation of the active principle of opium, whereby Seguin so nearly secured the glory of the discovery of the alkaloids. In 1811 Courtois was manufacturing artificial nitre, and exp

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Lithium.

Lithium, the oxide of which was discovered in 1807 by Arfwedson, was first suggested as a remedy for gout by Dr. Ure in 1843. He based his proposal on an observation by Lipowitz of the singular power of lithium in dissolving uric acid. Dr. Garrod popularised the employment of the carbonate of lithium in medicine. Most of the natural mineral waters which had acquired a reputation in gouty affections have been found to contain lithium....

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Magnesia.

The first use of carbonate of magnesia medicinally was in the form of a secret medicine which must have acquired much popularity in the beginning of the eighteenth century. It was prepared, says Bergmann, by a regular canon at Rome, sold under the title of the powder of the Count of Palma, and credited with almost universal virtues. The method of preparation was rigidly concealed, but it evidently attracted the attention of chemists and physicians, for it appears that in 1707 Valentini published

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Nitre

among the ancient Greeks and Romans generally meant carbonate of soda, sometimes carbonate of potash. The Arab chemists, however, clearly described nitrate of potash. In the works attributed to Geber and Marcus Græcus, especially, its characters are represented. Raymond Lully, in the thirteenth century, mentions sal nitri, and evidently alludes to saltpetre, and Roger Bacon always meant nitrate of potash when he wrote of nitre. It was not, however, until the seventeenth century that the term acq

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Petroleum.

Under the name of naphtha and other designations petroleum has been known and used from the earliest times. The Persians were the first, as far as is known, to employ it for lighting, and also for cooking. They likewise made use of it as a liniment for rheumatism. So in this country, a kind of petroleum was sold as a liniment under the name of British oil; and in America, long before the great oil industry had been thought of, petroleum was popular as a liniment for rheumatism under the name of

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Phosphorus.

Phosphorus, or its Latin equivalent, Lucifer, was the name given by the ancient astronomers to the planet Venus when it appeared as a morning star. When it shone as an evening star they called it Hesperus. Do we invent such seductive names now, or do they only seem attractive to us because they are ancient or foreign? The phosphorescent properties of certain earths had been occasionally noticed by naturalists, but no observation of the kind has been traced in ancient writings. The earliest allus

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The Hypophosphites.

The hypophosphites in the form of syrup were introduced by Dr. J. F. Churchill, of Paris, as specifics in consumptive diseases about 1857. His preference of these salts over the phosphates was based on the theory that the deficiency in the system in a phthisical condition was not of phosphates, which had been completely oxidised, but of a phosphide in an oxidisable condition, and this requirement was fulfilled by the hypophosphites. The latter he compared to wood or coal, the phosphates to ashes

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Sal Prunella

was at one time in high esteem, as it was believed that by the process adopted for making it the nitre was specially purified. Purified nitre was melted in an iron pot and a little flowers of sulphur (1 oz. to 2 lb.) was sprinkled on it, a little at a time. The sulphur deflagrating was supposed to exercise the purifying influence on the nitre. The actual effect was to convert a small part of the nitrate of potash into sulphate. It was first called Sal Prunella in Germany from the belief that it

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Sal Gemmæ.

Sal Gemmæ or Sal Fossile was the name given to rock salt, particularly to the transparent and the tinted varieties. It was believed to be more penetrating than the salt derived from sea water, and this property Lemery ascribed to the circumstance that it had never been dissolved in water, and therefore retained all its native keenness....

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Spirit of Salt.

Spiritus Salis Marini Glauberi was one of the products discovered by Glauber, to whom we owe the name of spirit of salt. He was a keen observer and remarked on the suffocating vapour yielded as soon as oil of vitriol was poured on sea-salt. It is astonishing to his biographers that he just missed discovering chlorine. The spirit of salt was highly recommended for many medicinal uses; for exciting the appetite, correcting the bile, curing gangrene, and dissolving stone. Its remarkable property of

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Tartar.

Tartarus was the mythological hell where the gods imprisoned and punished those who had offended them. Virgil represents it as surrounded by three walls and the river Phlegethon, whose waters were sulphur and pitch. Its entrance was protected by a tower wrapped in a cloud three times as black as the darkest night, a gate which the gods themselves could not break, and guarded by Cerberus. There is nothing to associate this dismal place with the tartar of chemistry, except that in old books it is

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Vitriol.

Visitando Interiora Terræ Rectificando Invenies Occultum Lapidem Veram Medicinam. (Visiting the interior of the earth you may find, by rectifying the occult stone, the true medicine.) This acrostic is first found in the works attributed to Basil Valentine. The vitriols enjoyed an enormous reputation in medicine, at least until their chemical composition was definitely explained by Geoffrey in 1728. It was certainly known that the green vitriols contained iron, and they were sometimes named vitri

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ANTIMONY.

Some of the old writers insisted that antimony (the native sulphide) was used as a medicine by Hippocrates who called it Tetragonon, which simply meant four-cornered, and of which we also know that it was made up with the milk of a woman. The reason which the iatro-chemists gave for believing that this compound was made from antimony was worthy of the age when it was the practice to apply enigmatic names to medicinal substances, a practice, however, quite foreign to Hippocrates. They understood

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BISMUTH.

Bismuth, the metal, was not known to the ancients nor to the Arabs. It was first mentioned under that name by Agricola, in 1546, in “De Natura Fossilium,” and was not then regarded as a distinct body. Agricola considered it to be a form of lead, and other mining chemists believed that it gradually changed into silver. The Magistery (trisnitrate or oxynitrate) was the secret blanc de fard which Lemery sold in large quantities as a cosmetic. He bought the secret from an unknown chemist and made a

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GOLD.

The employment of gold as a remedy is but rarely mentioned in ancient medical literature. Gold leaf was probably used by the Egyptians to cover abrasions of the skin. Pieces of it have been found on mummies apparently so applied. Some of the Arab alchemists, Geber among them, are believed to have made some kind of elixir of life from gold, but their writings are too enigmatical to be trusted. Avicenna mentions gold among blood purifiers, and the gilding of pills originated with the Eastern pharm

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IRON.

Iron was not regarded as of special medicinal value by the ancients. The alleged administration of the rust of iron by Melampus was apparently looked upon as a miracle, and though this instance is often quoted as the earliest record of ferruginous treatment, it does not appear to have been copied. Classical allusions, such as that of the rust of the spear of Telephus being employed to heal the wounds which the weapon had inflicted, which is referred to by Homer, can hardly be treated as evidence

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LEAD.

Lead is one of the ancient metals and was associated in classical writings with Saturn. The lead compounds used by the ancients in medicine were white lead or ceruse (carbonate and hydrate), and litharge (oxide). Ceruse is supposed to owe its name to cera, and to mean waxy; litharge is from Greek, and means silver stone; it was regarded as the scum of silver. Red lead or minium was also used to some extent in the form of an ointment. Although not much used now as a medicine for internal administ

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QUICKSILVER

is first alluded to in Greek writings by Theophrastus, about 315 B.C. , but it was certainly known and used medicinally by the Chinese and in India long before. Apparently, too, it was known by the Egyptians. Dioscorides invented the name hydrargyrum, or fluid silver, for it. Pliny treats it as a dangerous poison. Galen adopted the opinion that the metal is poisonous, but states that he had no personal knowledge of its effects. With these authors argentum vivum was the term generally used to mea

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SILVER.

The moon was universally admitted under the theory of the macrocosm and the microcosm to rule the head, and as silver was the recognised representative of Luna among the metals the deduction was obvious that silver was the suitable remedy for all diseases affecting the brain, as apoplexy, epilepsy, melancholia, vertigo, and failure of memory. Tachenius relates that a certain silversmith had the gift of being able to repeat word for word anything that he heard, and this power he attributed to his

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TIN.

Tin came into medical use in the middle ages, and acquired its position particularly as a vermifuge. For this purpose tin had a reputation only second to mercury. Several compounds of this metal were popular as medicines both official and as nostrums in the seventeenth and eighteenth centuries, and tin did not drop out of medicinal employment until early in the nineteenth century. The beautiful mosaic gold (aurum musivum), a pet product with many alchemists, was probably the first tin compound t

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ZINC.

The earliest known description of zinc as a metal is found in the treatise on minerals by Paracelsus, and it is he who first designates the metal by the name familiar to us. Paracelsus says: “There is another metal, zinc, which is in general unknown. It is a distinct metal of a different origin, though adulterated with many other metals. It can be melted, for it consists of three fluid principles, but it is not malleable. In its colour it is unlike all others, and does not grow in the same manne

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ERRATUM.

The acknowledgment at the foot of page 308, of the source of the symbols illustrated on that page, is incorrect. The symbols in question are reproduced from Mr. C. J. S. Thompson’s book, The Mystery and Romance of Alchemy and Pharmacy , published by the Scientific Press, Ltd. CHRONICLES OF PHARMACY Their next business is, from herbs, minerals, gums, oils, shells, salts, juices, sea-weed, excrements, barks of trees, serpents, toads, frogs, spiders, dead men’s flesh and bones, birds, beasts, and f

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Animal Substances in Pharmacy.

The inclination to find medicinal virtues in parts of animals is not altogether unreasonable in its origin. Savages eat the hearts of lions and tigers to acquire some of the courage and fierceness of those beasts; and a similar instinct would suggest various organs of animals for use in medicine. The employment of foxes’ lungs in asthmatic and bronchial complaints, for example, seems a most natural remedy to try, and as the lohoch, in which form these lungs were generally administered, was made

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Officially Recognised Animal Medicines.

Remedies obtained from the animal kingdom were employed by the Egyptian, the Greek, and the Roman physicians. The Arabs, though they introduced musk, kermes, and bezoar into medicine, were not largely interested in animal products in their materia medica. The adoption of revolting preparations of this class developed rapidly in the sixteenth and seventeenth centuries, curiously enough alongside the introduction of the new chemical remedies. The appended list of animals and animal products which

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Homo: Man as a Medicine.

Man being the microcosm of the universe (the macrocosm) medicines of human origin figured very prominently in old pharmacopœias. In Lemery’s “Dictionnaire Universelle des Drogues Simples,” which was a standard authority all over Europe, at least until the end of the eighteenth century, the author presents a summary of the medicinal uses to which the various parts of “Homo” were applied. I quote (but slightly abbreviate) from the edition of Lemery’s Dictionary of 1759:— “All parts of man, his exc

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Cow-Dung as a Medicine.

A female pharmacist is mentioned in Salmon’s “Bate’s Dispensatory” (1694), who, he says, made a fortune of £20,000 by selling a tincture made from cow-dung. Her formula was, cow-dung, fresh gathered in the morning, 12 lbs.; spring or rain water, 30 lb. Digest for twenty-four hours, let it settle, and decant the clear brown tincture. Salmon says it is no doubt a good medicine, and has been much used with success. “It has a pretty kind of sweet scent as if it was perfumed with musk or some other o

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Excrements as Medicines.

It will be observed from the list of the excrements used in medicine officially recognised in the early London Pharmacopœias already given that those from various animals were specified. Excrements as remedies are at least as old as Dioscorides, whose work contains a special chapter devoted to an appreciation of the distinguishing virtues of the various sorts of dungs. Pliny likewise names many sorts, and states what are their particular properties. It is evident that these substances became ver

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Miscellaneous Animal Remedies.

It is not possible in a short space to exhaust this unsavory topic, but a few of the more notable applications of animals or animal derivatives may be briefly mentioned. Pigeons were cut in half while they were alive and applied to the feet of patients. Pepys alludes two or three times to this and always as an indication that the case is nearly hopeless. The Queen of Charles II was one of the instances. Oil of Puppies was made by cutting up two newly born ones and boiling them in a varnished pot

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Bezoar Stones.

Bezoar stones acquired their fame in the East, and were introduced to European medicine by the Arabs. The name is of Persian origin, Pad-zahr, meaning an expeller of poisons. The earliest reference known to Bezoar stones in Europe is by Avenzoar, an Arab physician who practised in Seville about the year 1000. They were included in the London Pharmacopœias from 1618 to 1746. There were many kinds of bezoar stones sold. The most esteemed was the lapis bezoar orientale. This came from Persia and wa

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Gascoyne’s or Gascoign’s Powder.

In the paper by Mr. Slare read before the Royal Society already referred to the author comments with similar severity on the then popular Gascoign’s Powder. As evidence of the fame it possessed he says he had been told that a certain “grandee of the faculty” had got above £50,000 by prescribing this compound. I suppose this meant he had received that amount in fees for prescriptions ordering that medicine. Taking advantage of the reverence in which bezoar was held by that generation, Gascoign’s

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Vipers.

Both in ancient and comparatively modern times vipers have been held in the highest esteem for their medicinal virtues, and viper fat, viper broth, and viper wine are used to this day in some remote parts of Britain, and to a still greater extent on the Continent. In some districts of France heads of vipers enclosed in little silk bags are worn by children to preserve them from croup and convulsions. It was the addition of vipers to the confection of Mithridates that constituted the principal im

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Mummies.

The employment of mummies in medicine does not seem to have been very ancient, nor did it become permanent. Who introduced it is not known. Ephraim Chambers in his Cyclopœdia (1738) says, “Mummy is said to have been first brought into use in medicine by the malice of a Jewish physician, who wrote that flesh thus embalmed was good for the cure of divers diseases, and particularly bruises, to prevent the blood’s gathering and coagulating.” Pomet also says that a Jewish physician had written about

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Dippel’s Animal Oil.

Animal oil, oil of harts’ horns, or empyreumatic oil, as it was variously called, or Dippel’s animal oil, which was the original, was highly prized as a medicine in the eighteenth century, and disputed the palm for nastiness with the balsam of sulphur. Dippel made it from harts’ horns, but later formulas directed it to be made from any bones, from blood, or indeed from any animal substance. In distilling the horn some water first came over, and this was rejected. At the end of the operation the

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Spermaceti.

“The sovereign’st thing on earth was parmceti for an inward bruise.”— Henry IV. Part I, Act I, Sc. 3. Woodall (1639) writing of spermaceti, says, “It is good also against bruises inwardly taken with Mummia.” Culpepper (1695) says, “Sperma Cœti is well applied outwardly to eating ulcers, and the marks which the small-pox leaves behind; it clears the sight, provokes sweat. Inwardly, it troubles the stomach and belly, helps bruising and stretching the nerves, and therefore is good for women newly d

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Honey

is one of the oldest of food products, and was the only sweetening substance in popular use until quite modern times. Sugar was known in India and was imported into Greece and Rome at very early periods. The name saccharum is of Sanskrit origin, and therefore testifies to its ancient lineage, and allusions to it, likening it to honey, are to be found in the writings of many of the classic naturalists from Herodotus onwards. The Arabs, who had long brought sugar from India to the wealthy West, ma

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Precious Stones.

Marvellous virtues were attributed by the ancients to the precious stones known to them, but rather perhaps in their character of amulets than as medicines. One of the so-called hymns of Orpheus, composed probably about 500 B.C. , is “On Stones,” and describes the properties of many of these highly esteemed minerals. Four lines (taken from a translation in the Rev. C. W. King’s “Natural History of Precious Stones”) will serve as a sample:— Coral, according to the same authority, acquired its spe

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The Four Officinal Capitals.

This description was applied in old medical books to Mithridatium, Venice Treacle, Philonium, and Diascordium. There were writers who ventured to criticise some of the details of composition, or some of the uses frequently made of these compounds, but the possibility of medicine existing without them was hardly contemplated previous to the eighteenth century. Of the two confections first named much has been said in other chapters; but it may be of interest to present here a conspectus of the ing

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Philonium,

a famous antidote invented by Philon of Tarsus, who is supposed to have lived in the early part of the first century (a contemporary probably of Saul of Tarsus). Galen says of it that it had been in great reputation for a long time, and was one of the earliest of the compounds of the kind. Philon gives his formula in Greek verses and in such enigmatic language that it would be impossible to interpret it if Galen himself had not come to the rescue. Philon writes:— Take of the red and odorous hair

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Diascordium,

the last of the four officinal capitals, was a medicinal compilation by Hieronymus Frascatorius, and is given in his book “De Contagio et Morbis Contagiosis.” It was devised as a preventive of plague, but it acquired such popularity that Dr. James in the introduction to his Dispensatory (1747) writing of the conventional esteem in which so many compounds are held, says, “Thus the Venice Treacle invented by Andromachus under the reign of Nero, and the Diascordium of Frascatorius, have been used b

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Theriaca.

Theriaca was invented by Nero’s physician, Andromachus, and was devised as an improvement on Mithridatium which until then was the great antidote in Roman pharmacy. The most important addition which appeared in the new formula was the introduction of vipers. Andromachus named his electuary “Galene,” which meant tranquil, probably to suggest that it was a soothing, anodyne medicine. It soon, however, acquired its permanent name, for it is referred to as Theriaca by Pliny, who would have been a co

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Kermes.

Kermes as a pharmaceutical term reaches us through the Arabic, qirmis, red. But it was not a native Arabic word. It was adopted into that language from the Persian, and was of Sanskrit origin. The word Krimija in Sanskrit meant produced by a worm, and was itself from krimi, a worm; worm is the direct English descendant of krimi. Kermes is responsible in modern English for carmine and crimson, but it need hardly be said that it has no connection with the Flemish kermess though it looks so like it

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Mel Ægyptiacum

is a very ancient compound used chiefly by veterinarians as an escharotic. Its name suggests Egyptian origin, but it has not been traced further back than to the “Grabadin” of John Mesué, the Arabian author, about the year 800. Scribonius Largus before him gives a similar formula under the name of Hygra. Mesué’s formula was to boil 1 oz. of vinegar with 1 oz. of honey to the consistence of honey and to add 2 drachms of verdigris. This formula was modified in various ways in the different pharmac

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Terra Sigillata.

Various earths were celebrated as medicines in old times, that from the Island of Lemnos especially having been esteemed from the days of Herodotus among the Greeks, and this product retained its reputation in Western Europe down to the seventeenth century. It is still used by the Turks and neighbouring nations. The Lemnian earth is a greasy clay which is dug from a desolate hill in the island and consists of silica, alumina, chalk, and magnesia, with a little oxide of iron which gives it a red

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Oil of Bricks.

Oil of Bricks appeared in the earlier London and Edinburgh pharmacopœias and in many foreign formularies. It was long held to be a specially valuable application in gouty and rheumatic pains, and was especially in repute as a cure for deafness. It was also sometimes given as an internal remedy. Among its synonyms were those of oleum philosophorum, oleum sanctum, oleum divinum, and oleum benedictum; but as these names were adopted for selling purposes they may not have meant much. The process giv

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Arquebusade Water

was the original of many vulnerary waters invented for application to wounds, bruises, and ulcers. It was a weak, spirituous distillate from a large number of herbs and aromatic plants, such as angelica, rosemary balm, hyssop, mint, rue, sage, and wormwood. These would furnish an antiseptic lotion. As the arquebus was displaced by the musket about the end of the sixteenth century it may be supposed that the lotion acquired its name and popularity at that same period; but these evidently lasted f

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Four Thieves Vinegar

is the sub-title of the Antiseptic Vinegar of the French Codex. It is a strong vinegar in which a number of aromatics with camphor and garlic have been macerated. The story of its origin is that in the year 1720 a plague was raging in the city of Toulouse, and that during the period of panic four thieves went about the city plundering the dead and dying. People wondered why they never took the disease, and when they were ultimately brought to justice and convicted, they were offered pardon if th

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Elixir Proprietatis.

This medicine was very celebrated in all countries for several centuries, and, though not in the British Pharmacopœia, was official under the name which Paracelsus gave it in the P.L. 1724, as Elixir of Aloes in the P.L. 1746, and later as Tinct. Aloes Co. In the Ph. Ed. it was called Tinct. Aloes et Myrrhæ, and this was the most usual name for it until quite recent times, and probably is still. Paracelsus wrote about it and extolled it as a compound which would prolong life to its utmost limits

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Balsam of Sulphur

was a famous medicine up to our own days. It appears now to have dropped out of use. It was highly commended by Van Helmont, Rulandos, Boyle, and indeed by most of the medical experts of the seventeenth century, and was compounded from many different formulæ. The simple balsam was made by boiling one pound of flowers of sulphur with four times its weight of olive oil until the sulphur was dissolved and a thick dark balsamic substance was obtained. This was the formula of the P.L. 1746. But linse

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The London Pharmacopœia.

The collection of medicinal formulas was a favourite occupation of ancient medical writers. Galen and Avicenna, Mesué and Serapion, Nicholas Prepositus and Nicolas of Salerno were the authors of the dispensatories most esteemed up to the sixteenth century in Europe. The College of Medicine of Florence adopted an Antidotarium in the early part of that century, and in 1524 the Senate of Nuremberg made the Dispensatory of Valerius Cordus official in that city. Augsburg followed the example of Nurem

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The Apothecary in “Romeo and Juliet”

is a favourite illustration of the scrupulous care which Shakespeare bestowed on the revision of his dramas. The story on which the play is founded is well known to students. It was written by an Italian novelist, Luigi da Porto, of Vicenza, and was entitled “La Giuletta.” This author died in 1529. In Girolamo de la Corte’s “History of Verona,” published at Venice in 1549, it is given and stated to be a true story. An English translation of it in rhyme by Arthur Brooke appeared in 1562, and a pr

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Shakespeare’s First Rendering.

This is the rendering of the scene from Shakespeare’s first quarto edition, 1597: Shakespeare was a busy man in 1597, and in the years before as well as about that date he was preparing novelties for his theatre. Later he had more leisure, and it is interesting to notice how artistically he fills out his original sketch with only just such details as make the ideas more vivid. In the revised version of this scene, published in 1609, there are no new ideas, but scarcely a line is left untouched.

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Shakespeare’s Revised Version (Third Quarto, 1609).

The Apothecary. (Drawn by Miss K. Righton.) Two lines in the accepted version have been the subject of much controversy, sometimes of an acrimonious character among critics. Both sides quote one or other of the early editions in support of their contentions. One of the lines is “Need and oppression starveth in thy eyes.” It is fiercely held that “starveth” in this expression should be “stareth.” And in the famous line “I pray thy poverty and not thy will” ordinary readers naturally think “pay” s

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Hebenon.

The “juice of cursed Hebenon,” which according to the Ghost, was the poison chosen by Hamlet’s wicked uncle to kill his father by dropping some of it into his ears during his afternoon nap, has been much discussed by commentators. Authorities generally favour either henbane or ebony (hebenus). Some occasional opinions may be found suggesting other poisons, but they do not carry much weight. Dr. Paris, for example, in “Pharmacologia” proposes the essential oil of tobacco, quoting in support of hi

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Aloes.

Dioscorides is the earliest medical writer to mention aloes as a medicine. According to him it should be given in doses of from half a drachm to one drachm as a gentle purge, or of three drachms if its full cathartic effect were required. The drug is not named by Hippocrates nor by Theophrastus. Celsus describes it as specially valuable for city men and men of letters (urbani et literarum cupidi); he says it is an ingredient in all purgatives, and it is clear from the later Greek and Roman write

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Castor Oil.

The supposed identity of the Palma Christi tree, from the seeds of which castor oil is obtained, with the Hebrew “kikaion” is mentioned in the note on Jonah’s “gourd” in the section “Pharmacy in the Bible.” It is not doubtful that the plant was the same as the “kiki” of Herodotus, and the “kiki” or “kroton” of Dioscorides. Avicenna quotes a reference to the seeds from Dioscorides, from which, he says, is pressed the oil of kiki “which is the oil of Alkeroa.” Other Arab authors use the term “al-k

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Cinchona.

It is not possible to determine from the legends and reports collected by the many competent naturalists who visited Peru in the seventeenth and eighteenth centuries with the special object of investigating the history of the cinchona trees whether it was known or used as a medicine by the natives before its virtues were ascertained by Europeans. Peru was discovered in 1513, and became subject to Spain about the middle of the sixteenth century. But Hanbury points out that no reference to the bar

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Tinct. Cinchonæ Co.

The official formula for this tincture is slightly modified from that devised by John Huxham, M.D., and published in his Essay on Fevers, 1755. It first appeared in the P.L. 1788 as a College preparation. John Huxham was born as Totnes in 1692, and was the son of a butcher. He studied medicine under Boerhaave at Leyden, but graduated M.D. at Rheims. Then he returned to England and after a time settled at Plymouth. He was a Nonconformist, and at first depended on the dissenting portion of the pop

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Cinchona or Chinchona.

Sir Clements Markham, whose services in introducing cinchona culture into India and Ceylon are well known, has earnestly insisted on the adoption of the name chinchona instead of cinchona in justice to the lady after whom the generic title was chosen. In a Memoir of the Lady Ana de Osorio, Countess of Chinchon, Sir Clements Markham somewhat extravagantly exalts that “illustrious and beautiful lady,” whom he describes as “one of the most noble benefactors of the human race.” She may have been an

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Cultivation of Cinchona in the East.

Many botanists and travellers remarked upon the reckless manner in which the natives of Peru collected the bark. They felled the trees and stripped them of bark without planting new ones to take the place of those destroyed. Humboldt says that 25,000 trees were thus destroyed in a single year. The first attempt to transport any plants to Europe was made by La Condamine in 1743. He had obtained some young plants and was conveying them down the Amazon River to Cayenne, intending to transport them

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Cubebs

have had a rather chequered medical history. The Arab physicians used them apparently for the same medicinal purposes, that is, for checking urethral discharges, as they are generally prescribed for by our own physicians; but in the middle ages we hear of them as a popular but costly condiment. Curious particulars of this use of cubebs are given in “Pharmacographia.” They were an ingredient in the P.L. formulas for Mithridate and Theriaca, probably as a stimulant. Then they seem to have dropped

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Digitalis.

Foxglove, the common and ancient name of this handsome plant, is believed to be a corruption of a still older name, Foxes’ glew, or Foxes’ music, in allusion to an instrument consisting of a series of bells hanging from one support. The Norwegian name of the plant is Rev-bjelda, fox-bells. A pretty fancy, but one which is not supported by evidence, is that the original name was folks’ glew, or fairy bells. In Scotland the flower is called bloody fingers, and sometimes dead men’s bells; in France

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Guaiacum

Came into fame in Europe in the early years of syphilis. The story told about it (perhaps it was only a clever advertisement, though it is related without any question by Leclerc) was that a certain Spaniard named Gonsalvo Ferrand having taken the disease and finding no cure for it resolved to go into the countries from which the infection had come, confident that he would there find the remedy which the natives themselves employed. He went to St. Domingo, discovered that the wood there called H

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Ipecacuanha.

Although several earlier allusions to ipecacuanha have been found, the first being in an account of Brazil by a Portuguese friar given in Purchas’s “Pilgrimes” (1625), where the medicine is named Igpecaya and is described as a remedy for the bloody flux, its effective introduction to European medicine was in the year 1686, when Louis XIV bought from Jean Adrien Helvetius the secret of a medicine with which he had performed a number of remarkable cures of diarrhœa and dysentery. Helvetius, whose

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Kousso.

Although Bruce, the African traveller and others had described the tree which bears the kousso flowers in Abyssinia (Hagena Abyssinica) and had noted that the natives used these as worm medicine, the first knowledge of them actually made use of came through a French physician named Brayer residing in Constantinople about the year 1820. Brayer was one day in a café where was a waiter extremely emaciated and who suffered cruel pains from tapeworm. An old Armenian came into the café and told this w

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Opium.

The ancients recognised two kinds of opium. The superior kind was called opion, and was the juice which exuded from the poppy head while it was growing; and the second quality, which was named meconion, was an extract made from the crushed heads and leaves of the poppy. It is doubtful whether Hippocrates was acquainted with the juice of the poppy at all. He refers to mecon but he attributes to it a purgative as well as a narcotic power; it is therefore probable that he alludes to some other plan

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Quassia

was sent to Linnæus from Surinam in 1763 by C. D. Dallberg, one of his pupils, with the statement that it formed the basis of a secret remedy employed there by a negro slave in endemic malignant fevers. The negro’s name was reported as Quassi, and from this Linnæus invented the name of quassia. This bitter wood was obtained from a shrub growing in Dutch Guiana, but for the English market it was subsequently superseded by the wood of a large tree growing in Jamaica, belonging to the same genus. T

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Sarsaparilla.

Sarsaparilla was introduced to Europe early in the sixteenth century, and soon leaped into fame. The great Emperor Charles V, was cured of gout by it, or fancied he was, and this gave it an enormous advertisement. It appeared afterwards that it was really China root, another smilax, that was given to the Emperor, but it was called sarsaparilla, and the western medicine got the glory. Sarsaparilla was vaunted as a cure for syphilis, but physicians were not long in discovering that it was much mor

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Stramonium

may have been known to the ancients as a poison. Dioscorides included it among the henbanes, and Avicenna is supposed to have described it under the name of the Methel nut. Some species of Datura were frequently used in Eastern countries by thieves and sorcerers to induce delirium and subsequent coma, and the herb had the worst of reputations when Störck, of Vienna, experimented with it first on himself about 1765. In consequence of its action on the brain he gave it in cases of mania and epilep

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Black Draught.

Laxative or cathartic potions have been prescribed in all modern pharmacopœias, most of them being preparations of senna. The original one was devised by Mannagetta, an Italian physician at the court of the Emperor Rudolph II, about 1600. His prescription became popular under the title of Aqua, or Potio Laxativa Viennensis, and was popularly known all over Germany as “Wiener Trank.” The formula was 1 oz. of senna, 6 drachms of currants, 2 drachms of coriander seeds, and 2½ drachms of cream of ta

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Blaud’s Pills.

These pills are probably taken in larger numbers than any other pills sold in Great Britain. If in proper condition they present iron in the form of the protocarbonate, either formed in the pills, or perhaps partially or entirely in the stomach. They are similar to Griffiths’ pills, which were the popular Mist. Ferri Co. in pilular form. Dr. J. Blaud, a French provincial practitioner, in an article published in the Revue Medicale , in 1831, entitled “Memoires sur les Maladies Chlorotiques,” gave

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The Chelsea Pensioner.

An electuary for rheumatism bearing this title was evidently popular under the above name in the early part of the nineteenth century, but I have not been able to discover where or when or with whom it originated. The compilers of books of formulas naturally copy from each other, and consequently a legend once started is likely to become crystallised. In The Chemist and Druggist , of June 13th, 20th, and 27th, 1896, an attempt was made to track this medicine to its origin, and a number of old fo

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Citrine Ointment.

An ointment thus named appeared first in the P. L. 1650. It was a compound of coral, limpet shells, quartz, white marble, white lead, and tragacanth incorporated into a basis of hogs’ lard, suet, and hens’ grease. It was reputed useful for certain skin complaints, freckles, etc. In the P.L. 1678 some of the old ingredients were omitted, sugar of lead was substituted for the white lead and rose water, and frankincense and citron bark were added. Nitrate of mercury ointment appeared first in the E

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Cold Cream.

The Unguentum Refrigerans, also called “Ceratum,” appeared in the first P.L., the formula being attributed to Galen. Four ounces of white wax were melted in 1 lb. of rose oil (ol. rosarum omphacinum, that is, olive oil in which rose buds 4 oz. to the lb. had been macerated, the maceration being carried out three times, each time with a fresh lot of roses). The melted oil and wax were to be poured frequently from one vessel to another, stirring in a little cold water meanwhile, until the mixture

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Diachylon Plaster.

The original formula for this plaster was compiled by Tiberius Claudius Menecrates, who lived in the reign of the Emperor Tiberius, and was probably his physician. In a Greek inscription discovered at Rome he is described as Physician of the Cæsars, probably Tiberius, Caligula, and Claudius, for he died in the reign of the last named. He wrote a great work on remedies entitled “Autocrator Hologrammatos,” literally, “The Emperor, whose words are written in full.” Probably the book was dedicated t

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Dover’s Powder.

Thomas Dover, to whom we owe “Dover’s Powder,” practised as a doctor in London in the first half of the eighteenth century. He was born and buried at Barton on the Heath in Warwickshire in 1660. How he got his medical training is not on record, but some time in his youth he lived in the house of Thomas Sydenham, the famous physician, from whom probably he acquired his independent ideas of medical treatment, and possibly the germ of his lack of reverence for the College of Physicians. While livin

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Unguentum Elemi.

Ointment of elemi was in all the London Pharmacopœias, and was only dropped from the B.P. 1898. In the earlier issues it was called “unguentum or linimentum Arcœi,” because it had been introduced and recommended by Arcœus of Amsterdam in 1574, for healing wounds. A similar ointment was called “Balsamum Arcœi” in the Prussian Pharmacopœia of 1847. The inventor’s formula was to melt together six parts each of gum elemi and turpentine, and add six parts of melted stag’s suet, and two parts of oil o

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Fowler’s Solution of Arsenic.

Thomas Fowler kept an apothecary’s shop in York from 1760 to 1774. In the latter year he relinquished trade, and went to Edinburgh to study medicine. Graduating as M.D. in 1778, he settled at Stafford, and was appointed physician to the Infirmary of that town. Later, he returned to York, where he acquired a large practice, and where he died in 1801. It was in 1786, during his residence at Stafford, that Dr. Fowler published his treatise, entitled “Medical Reports of the Effects of Arsenic in the

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Friar’s Balsam.

Tinct. Benzoin Co., was a copy of Ward’s Balsam, which itself was only the adaptation of compounds which had been for a long time sold under the names of Friar’s Balsam, Commander’s Balsam, Jesuit’s Drops, Turlington’s Drops, and Traumatic Balsam. It was under the last name that it first appeared in the P.L. of 1746. This was only the Latinised name of Wound Balsam, another old designation of a similar preparation. It is not known how the still popular name for this preparation, Friar’s Balsam,

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Gregory’s Powder.

The original of the Pulv. Rhei Co. of the British Pharmacopœia was a prescription very frequently given by Dr. James Gregory, of Edinburgh, in his time the most famous physician of that city. He died in 1822. This Dr. Gregory was Professor of Medicine in Edinburgh University, as his father was before him. His son became Professor of Chemistry in the same university. Direct ancestors of these Gregorys had been professors of history, astronomy, and mathematics at Edinburgh, Oxford, and St. Andrews

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Hiera Picra.

A medicine with this familiar name can be bought in any chemist’s shop in Europe or America to-day, just as it could in Damascus a thousand, or in Rome and Alexandria two thousand years ago. Probably it is the oldest pharmaceutical compound still in existence. Through all the centuries the hiera picra known to the public has been a preparation of aloes. The adjuncts have varied but aloes has always been the essential ingredient, with one celebrated exception. The origin of this medicine is vario

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Laudanum.

Paracelsus probably invented the name of laudanum, and seems to have called several medicines by that term. In one place he expressly states that his laudanum was made from gold leaf and unperforated pearls; in other places he seems to mean red precipitate, and undoubtedly opium or a compound of it was sometimes intended. Crollius gives a formula for a pill mass, which he designates the laudanum of Paracelsus, which contained one-fourth of its weight of opium, to which were added henbane juice,

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Tinctura Lavandulæ Composita

has much fallen from its earlier glories. In the P.L., 1721, it was made with French brandy and twenty-seven other ingredients, including besides lavender, sage, rosemary, betony, borage, lilies of the valley, cowslips, balm, orange flowers, bay berries, cinnamon, mace, nutmegs, cardamoms, cubebs, aloes wood, ambergris, saffron, musk roses, and a few other less familiar flowers or cordials. The preparation was known as Palsy Drops, but I am not sure whether the official compound acquired this ti

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Lenitive Electuary.

The formula prescribed in the first London Pharmacopœia was as follows:—Raisins (stoned), polypody of the oak, Eastern senna, of each 2 oz.; herb mercury, 1½ handful; jujubes and sebestens, of each 20; maidenhair, violets, and cleaned barley, of each 1 handful; prunes (stoned), tamarinds, of each 6 drachms; liquorice, ½ oz. These drugs were to be boiled in 10 lb. of water to one-third of its volume, and to the strained liquor were to be added pulp of cassia fistula, tamarinds, prunes, sugar of v

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Compound Liquorice Powder.

Although this popular medicine was only made official by being adopted in the B. P. Additions, 1874, it had already acquired reputation as a pleasant laxative in household medicine, and had been familiar in German pharmacy for the better part of a century. It first appeared in the Prussian Pharmacopœia in 1799, and had been devised by a noted physician of Berlin, Dr. E. G. Kurella, who died in the year named. He called the mixture Pectoral Powder, and he made an electuary from similar ingredient

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Opodeldoc.

So far as can be traced Paracelsus first used the term opodeldoc (or as it is generally found in his works, opodelloch or opodeltoch). If he invented the word it is probable that he did not derive it from any etymological elements. Various suggestions have been made from time to time in explanation of the term, but without any sound basis. The most ingenious one is given by Hermann Peters in his “Pictorial History of Ancient Pharmacy.” He derives it from the first syllabic of opoponax, the secon

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Paregoric.

Paregoric Elixir originated with Le Mort, Professor of Chemistry at the University of Leyden from 1702 till 1718, when he died and was succeeded by Boerhaave. A modification of Le Mort’s formula was given in the P.L., 1721, as Elixir Asthmaticum, thus:—Honey and liquorice root, of each 4 oz.; flowers of benjamin and opium, of each 1 drachm; camphor, 2 scruples; oil of aniseed, ½ drachm; salt of tartar, 1 oz.; spirit of wine, 2 lb. Quincy (1724) says, “there is not any composition of our shops to

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Pil. Cochia.

Pil. Cochia originated with the Greco-Roman physicians, from Galen onwards, and all the formulas for it associate aloes with a more drastic purgative such as colocynth, which is the usual ingredient. The term, however, did not come into use until about the seventh century, and according to some authorities it was first formally adopted by Rhazes, the Arab. The predecessors of our pills were called “katapotia,” which meant things to be swallowed, and the earlier prescribers directed katapotia of

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Plummer’s Pills.

Pil. Calomel. Co. originated from a formula devised by Dr. Andrew Plummer, Professor of Chemistry in the University of Edinburgh in the middle of the eighteenth century. Dr. Plummer first published his formula in the “Edinburgh Medical Essays,” 1751. It was only a slight modification of the Pilulæ Æthiopicæ which were already official in the Edinburgh Pharmacopœia. These were originally a combination of Ethiops Mineral with the golden sulphide of antimony, but the Edinburgh College had substitut

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Ammoniated Tincture of Quinine.

Under this name Mr. Joseph Ince recorded in the Pharm. Journ. , June 13th, 1874, that a preparation was made and called by this name which was a solution of 1 grain of sulphate of quinine in one drachm of compound spirit of ammonia. This did not meet with general approval, and in 1853 Mr. Bastick proposed an Ammoniated Solution of Quinine made by dissolving 32 grains of sulphate of quinine in 3½ ounces of proof spirit and ½ ounce of solution of ammonia. The present B.P. tincture contains less am

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Compound Soap Pills.

Pil. Sapon. Co., formerly official as Pil. Sapon. c Opio, Pil. Opii, Pil. ex Opio, and when first authorised in the P.L., 1746, Pil. Saponacea, was adapted from a famous nostrum long sold as Matthews’s Pills, and as Starkey’s Pills. Starkey, a qualified physician, was understood to have devised the process, and Matthews was the vendor in whose name they were sold. But a little before his death in 1665 Starkey told Dr. George Wilson that the formula he had sold to Matthews was not his genuine and

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Decoctions of Sarsaparilla.

Sarsaparilla, guaiacum, sassafras, and mezereon enjoyed fitful periods of fame in the sixteenth, seventeenth and eighteenth centuries, especially for the treatment of syphilis. From the time of their introduction the Paracelsists denounced these remedies, and Paracelsus himself was especially sarcastic about “the wooden doctors,” as he called those who relied on these woods. Still they were employed to an immense extent. A number of remedies were made from them, generally from a combination of t

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Seidlitz Powders

are a well known misnomer. Fr. Hoffmann discovered the Seidlitz spring in 1724, and found that it owed its medicinal effect to sulphate of magnesia with some sulphate of soda. Seidlitz or Sedlitz is a small town near Seidschutz in northern Bohemia. There is evidence that at one time sulphate of magnesia was obtained commercially from this spring as it was from the Epsom water, and in this country then, and in some Continental countries still, Seidlitz salt was and is a synonym for sulphate of ma

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Turner’s Cerate.

Daniel Turner, M.D., the inventor of Turner’s Cerate, which appeared in several Pharmacopœias as Ceratum Calaminæ, was at first a surgeon in London, but was admitted a Licentiate of the College of Physicians in 1711, and practised in Devonshire Square, Bishopsgate. In William Munk’s Roll of the Royal College of Physicians an opinion of him is quoted that he was too fond of displaying his talents upon paper; the result being that he published many volumes which are now forgotten. (A commentary wh

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Patent Medicines.

In the early days of English commerce monopolies were granted by the sovereigns at their own pleasure, and often for their personal profit. Queen Elizabeth so largely abused her power in this direction that towards the end of her reign the discontent of her subjects compelled her to promise she would offend no more: and her successor, James I, gave a similar undertaking. The abuse, however, was continued until the Statute of Monopolies, passed in 1624, regulated all such grants, placing the powe

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Anderson’s Scots Pills.

These pills acquired extraordinary popularity, particularly in Scotland and France, and to some extent in other countries, including England. Either these pills or Singleton’s Eye Ointment is the proprietary remedy still sold in this country with the longest history. It is claimed that the ointment was invented some forty years earlier than the pills, but it must be admitted that the records of the latter, especially in their early days, are more exactly authenticated. Patrick Anderson, M.D. Dr.

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Anodyne Necklaces.

Anodyne necklaces were perhaps the most extensively advertised of the quack remedies of the eighteenth century. The introduction of them is generally attributed to one of the Chamberlen family, well known in medical history as the inventors of the modern midwifery forceps. In a collection of quack advertisements in the British Museum, all published in the last half of the seventeenth century, there is a handbill issued by Major John Coke, “a licensed physician and one of his Majesty’s Chymists”

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Daffy’s Elixir.

The Rev. Thomas Daffy, who invented the Elixir Salutis with which his name has been associated for about 250 years, was rector of Redmile in Leicestershire from 1660 to 1680. He had been appointed rector of Harby in the same county in Cromwell’s time, but the Countess of Rutland, who presumably “sat under” him, was a lady of evangelical ideas, and the Rev. Thomas was apparently of a “high” tendency, for according to Nichols’s “History of Leicestershire,” “he was removed from that better living t

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Baume de Fioraventi.

This medicine still figures in the French Codex and in other continental Pharmacopœias. It is an alcoholic tincture of canella, cloves, nutmegs, ginger, and other spices, with bay berries, to which are added amber, galbanum, myrrh, aloes, elemi, and other resins, and one-sixth by volume of turpentine. After digestion this mixture is distilled to a yield of about two-thirds of the original bulk. The balm was formerly given in doses of 5 or 6 drops in kidney disorders, but it is now only used exte

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Baume Tranquille

was originally made by the Capucin monk, Aignan, whose religious name was Father Tranquille. The Capucins of the Louvre were noted in the seventeenth century for their medical skill, and Father Tranquille was one of them. Twenty herbs were used in compounding this balsam, among them poppy, tobacco, lavender, and rue. These were infused in oil. “The Baume may be made still more effective,” writes Père Rousseau, who was a fellow monk with Father Tranquille, “by adding as many large live frogs as t

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Baume de Vie.

Baume de Vie, which is represented by Decoct. Aloes Co., B.P., was first sold by a French apothecary named Le Lievre, of the Rue de la Seine, Paris. A second edition of his book recommending it is dated 1760. He describes himself as “le sieur Lelievre apothicaire, distillateur du Roi.” He says of it that it gently evacuates the heterogeneous humours, restores and fortifies the stomach, reanimates the system without causing any fever or other inconvenience, preserves the humid radical (a fluid su

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Dutch Drops.

Haarlem Oil or Dutch Drops have been made in Haarlem since the year 1672, when they were invented by one Claas Tilly, and they are still manufactured in Haarlem by a person who claims to be a direct descendant of the inventor. The preparation is stated in Paris’s “Pharmacologia” to have as a base the residue left in the still after the redistillation of turpentine; a red, thick, resinous matter, sometimes called balsam of turpentine. But the same author adds that a preparation often sold as Dutc

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Godfrey’s Cordial.

The following advertisement which is taken from Reed’s Weekly Journal , February 22, 1722, throws light on the origin of the still popular “Godfrey.” To all retailers and others. The general cordial formerly sold by Mr. Thomas Godfrey, of Hunsdon, in Hertfordshire, deceas’d, is now prepar’d according to a receipt written by his own hand, and by him given to my wife, his relation, is now sold by me Tho. Humphreys of Ware, in the said county, Surgeon, or at John Humphreys, at the Head and Sheers i

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Eau des Carmes.

Eau de Melisse des Carmes, an aromatic spirit, recommended as a cordial for internal administration, and to bathe the temples, was first compounded in the pharmacy of the Barefooted Carmelites, near the Palace of the Luxembourg in the Faubourg St. Germain in 1611. In the course of the century the preparation became a valuable property, and though its composition was kept secret by the monks, formulas innumerable were published. Richelieu, Elizabeth of Bavaria, mother of the Regent during Louis X

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Goddard’s Drops.

The original formula for these is given as follows by Dr. William Salmon in his edition of “Bate’s Dispensatory”:— R. Humane Bones or rather scales, well dryed, break them into bits, and put them into a retort, and join thereto a large Receiver which lute well; and distil first with a gentle Fire, then with a stronger, increasing the fire gradatim; so will you have in the Recipient a Flegm, Spirit, Oyl, and Volatile Salt. Shake the Receiver to loosen the Volatile Salt from the sides, then close

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Eau Medicinale D’Husson.—Colchicum.

The medicinal use of colchicum preparations for gout is comparatively recent and the knowledge of its value for that purpose is undoubtedly due to its success in a secret proprietary remedy. The authors of “Pharmacographia” give some interesting historical notes on Colchicum autumnale , L., or meadow saffron, which show how general was the belief in its deleterious qualities in both classical and mediæval times. Dioscorides alludes to the poisonous properties of Kolchikon, which he says grew in

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James’s Powder.

The antimonial preparation which attained the most permanent popularity was Dr. James’s Fever Powders. The inventor, Dr. Robert James, was a life-long friend of Dr. Johnson. The two went to school together at Lichfield, in which town James at one time practised. He was also in practice in Sheffield and Birmingham before he came to London. He first settled in Southampton Street, Covent Garden, but removed later to Craven Street, Strand. He was a man of considerable attainments, and is described a

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St. John Long’s Liniment.

John St. John Long after he became famous was always reticent about his origin; but it was believed that he was the son of a basket maker, some said of the name of Driscoll, that he was born in or near Doneraile, and in his youth assisted his father: that later, being possessed of some artistic talent, he practised as a portrait painter in Dublin and afterwards in Limerick. An advertisement appeared in a Limerick paper of Feb. 10, 1821, which was as follows:— “Mr. John St. John Long, Historical

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Seignette’s Salts.

(Soda Tartarata, Sodii potassio-tartras, Rochelle salts, Sel de Seignette, Sal polychrestum Seignette.) Peter Seignette was an apothecary at Rochelle in the later half of the seventeenth century. He had at least a local scientific reputation, and a paper of his describing certain remarkable natural products of his locality was printed in the “Transactions” of the Academy of Sciences of Paris. A little before 1672 Seignette was making some soluble tartar (tartrate of potash), and inadvertently us

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Singleton’s Golden Eye Ointment.

An allusion to this renowned proprietary preparation will be found under Citrine Ointment, this Vol., page 126 , in connection with the several discordant guesses as to its composition which have been published by eminent authorities. The ointment is mentioned in this section also because of its long history. According to the statement published by its present proprietor it is the oldest proprietary remedy still sold in this country. The present proprietor, Mr. Stephen Green, inherited it from h

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Mrs. Stephens’s Cure for Stone.

Perhaps the most notable recognition of a nostrum in English history was the Act of Parliament passed in 1739 entitled “An Act for providing a reward to Joanna Stephens upon a proper discovery to be made by her for the use of the publick of the Medicines prepared by her for the Cure of the Stone.” Mrs. Stephens was a widow and professed to have received the recipe from her late husband. A number of persons in the higher classes of society had been cured, or believed they had been, by taking her

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Earl of Rochester as Quack.

The witty but profligate Earl of Rochester, well known in history as the boon companion of Charles II, especially in his debaucheries, frequently gave offence to that monarch by his impudence or his sarcasms. His best known epigram is that referring to On several occasions Rochester was ordered to leave the Court, but Charles always sent for him to come back again. In one of these absences it is recorded that he took lodgings in Tower Street under the name of Alexander Bindo and practised for a

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Warburg’s Tincture.

Dr. Carl Warburg, an Austrian doctor, compounded a tincture some seventy years ago which soon acquired an extraordinary reputation in the treatment of agues and malarial fevers. Although its formula was not disclosed, the Austrian Ministry of Health about 1848 put it on the list of medicines which had to be stocked by all pharmacists, fixed the maximum price at which it should be sold to the public at 2 fl. 30 kr. (about 5s.), and established a central depot in Vienna for its manufacture, paying

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Ward’s Remedies.

Joshua Ward, who was born in 1685 and died in 1761, was one of the most notorious and successful of English quacks. In Gray’s “Supplement” and in Paris’s “Pharmacologia” he is said to have been a footman and to have obtained his recipes from some monks while travelling on the Continent with his master. This story is not corroborated by contemporary accounts, nor is it adopted by the “Dictionary of National Biography.” [3] From these sources it appears that Ward came of a good family, and in earl

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The Whitworth Doctors

are almost forgotten now, but a century ago they were famous all over England. The Whitworth red bottle and the Whitworth drops are still more or less popular reminiscences of their pharmacy. The former was an embrocation, and the second an antispasmodic tincture. Both contained oil of thyme. Formulas are given in “Pharmaceutical Formulas,” published at 42, Cannon Street. The founder of the family of the Whitworth Doctors was John Taylor, originally a farrier, of Whitworth, then a village about

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Biblical Poisons.

No case of poisoning either suicidal, murderous, or accidental, is alluded to in the Bible, unless we regard the story of the wild gourds (2 Kings, ch. iv, v. 39) as coming within the last description. The suicide by poison of Ptolemeus Macron is mentioned in 2 Maccabees, ch. x, v. 13, but though this was a frequent practice among the Greeks and Romans when the New Testament was written, no allusion to it is found in the sacred writings. It may be that the apostles who include “pharmakeia” among

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Poisoning in Rome.

Livy tells the story of the earliest of the poison leagues. He is dependent on older historians for his facts, as the alleged events happened some three centuries before he wrote; about the year 330 B.C. in fact. A number of patricians died one after the other, their illnesses presenting similar symptoms, but the causes of these could not be traced. At last, however, a female slave gave information to the Ediles of a group of twenty Roman ladies of the highest position who, she said, occupied th

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Poisons in Ancient Times.

The poisons known to the ancients cannot be with certainty identified. The one to which the power of philtres was principally attributed was mandragora, which was said to produce various hallucinations and temporary madness. It is most likely, however, that in many of the cases where this drug is named the poison actually used was belladonna root. Hannibal, fighting against a large army of African rebels, simulated retreat, but left on the field of battle a quantity of vases of wine in which “ma

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Poisonings in the Middle Ages.

The belief in the skill of the compounders of philtres and mysterious charms grew rather than diminished in the Middle Ages and as alchemy developed. In Sir Walter Scott’s “Talisman,” the tale of the Crusades, the western physician says, “The oily Saracens are curious in the art of poisons, and can so temper them that they shall be weeks in acting upon the party, during which time the perpetrator has leisure to escape. They can impregnate cloth and leather, nay, even paper and parchment, with th

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Credulity in regard to Poisons.

Terror of poisons became epidemic in many countries, and eager credulity welcomed any alleged antidote. Ambrose Paré relates an incident in which he was an actor. He, a Protestant, was principal physician to Charles IX, the wretched author of the Massacre of St. Bartholomew. His story of the experiment which that king had made with a bezoar stone is related on page 18. There was also an Archduke Ferdinand of Austria who in the same century invented an antidote to poisons. It was composed of sapp

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The Marchioness of Brinvilliers

was one of the most interesting of the historic poisoners. She was the daughter of the civil lieutenant of Paris, Dreux d’Aubray, and her career as a criminal coincides with the early years of Louis XIV’s reign. She is described as elegant, “petite,” sweet in her disposition, and modest in her demeanour. According to her own confessions, produced at her trial, sometimes admitted, and sometimes denied by her (and characterised by Michelet as confused and impossible, and probably composed under th

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Tofana.

About the same time the woman Tofana was selling her Aquetta di Napoli in Italy, but she was not brought to justice until 1709, when she confessed to the Pope and the Emperor Charles VI that her drops contained arsenic, and that by them she had caused the deaths of more than six hundred persons. The Emperor repeated her story to his physician, Garelli, by whom it was communicated to Hoffmann, who published it in his “Rational Medicine.” She preferred to prepare her drops by rubbing arsenic into

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The Chambre Ardente.

After the execution of the Marchioness of Brinvilliers, secret poisoning, far from being suppressed, appears to have become almost fashionable. The Government at least pretended to believe in widespread conspiracies. It may have been a political trick, as has been alleged, to get rid of some inconvenient opponents; but, however this may have been, a special commission was appointed by the French Government to inquire into the truth of certain rumours, and this commission acquired the title of th

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Negro Cæsar’s Antidote.

In Prestwich’s “Dissertation on Poisons” (1775) an extract is given from the “Carolina Gazette” of May 9, 1750 stating that the General Assembly, the governing body of the colony, had authorised the publication of “Negro Cæsar’s Cure for Poison.” The General Assembly had purchased Negro Cæsar’s freedom, and granted him £100 a year for life as the price of this formula. It consisted of roots of plantain and wild horehound (? of each) 3 oz. boiled together in two quarts of water down to 1 quart an

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Arsenic Eating.

About the middle of the 19th century some discussion took place in various popular and medical journals in reference to the alleged practice of eating arsenic in Styria and the neighbouring countries. Drs. Christison, Swaine Taylor, and Pereira were somewhat more than sceptical, but several doctors and others wrote confirming the statements from their personal knowledge. One of the most notable testimonies was contributed by Dr. Craig Maclagan of Edinburgh in the “Edinburgh Medical Journal” (186

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Immunity.

The modern employment of serums in the treatment of zymotic diseases goes a long way towards explaining the fact of the immunity of individuals in respect to bacterial poisons. But the possibility of immunity against such poisons as arsenic, opium, or serpent venom appears to rest on a different basis. In 1896 Professor (now Sir) Thomas R. Fraser, M.D., F.R.S., reported to the Royal Institution a long investigation dealing with the alleged resistant power of certain tribes or sects in India, Afr

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Modern Toxicology.

Systematic and scientific investigation of alleged poisoning was scarcely known before the end of the eighteenth or the beginning of the nineteenth centuries. The advance of chemical and physiological knowledge, however, was soon applied to the more certain detection of the criminal use of toxic agents. Orfila’s “Traité de Toxicologie,” published in 1814, the result of a multitude of experiments, was the work which led the way in the establishment of exact tests. Dr. Swaine Taylor in England, Si

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ALKALOIDS.

The alkaloids extracted from vegetables are the ideal quintessences which the alchemical pharmacists of the sixteenth and seventeenth centuries sought so eagerly to obtain. Their characteristic property is that they are basic, that is, that definite salts can be formed from them by combination with acids. They all contain nitrogen, and have an alkaline reaction. Of all the popular vegetable drugs opium was the one more than any other tortured to yield up its essence. The early laudanums and extr

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ANÆSTHETICS.

The greatest triumph achieved in any department of medicine, and worthy, perhaps, to be described as almost, if not quite, the most beneficent discovery in the world’s history, is that of the successful employment of anæsthetics. This great glory belongs to the nineteenth century. Indian hemp had been employed for centuries in the East, mandragora had a classical reputation, and from time to time the possibilities of hypnotism had been expounded by one or another of its professors. But it is onl

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A Mysterious Anæsthetic.

A strange and little known story is told by Professor Franck. Van Swieten was a Dutch physician, a pupil of Boerhaave. He did not succeed in his native land so well as he ought to have done, for he was a devout Catholic. He went to Vienna, where he attained the highest medical position and the utmost esteem from his patroness, the Empress Maria Theresa. On May 1, 1771, three young gentlemen called on Van Swieten and were shown into his study. The professor was then an old man, 71 years of age. “

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SYNTHETIC REMEDIES.

The development of organic chemistry in the course of the nineteenth century is a subject so vast that it is mentioned in this place with something approaching despair. The great chemists who, in the latter part of the eighteenth and in the early years of the nineteenth century, had rescued their science from the superstitious and fantastic theories and conceits which had encumbered it, Lavoisier, Priestley, Scheele, Cavendish, Dalton, Fourcroy, Berzelius, and many others who might be named, dis

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A Pharmaceutical Vocabulary.

The subjoined list of technical terms is limited to the names of pharmaceutical processes, products, and apparatus; and only (as a rule, with some exceptions) of such as are not dealt with in other sections. Many of the terms are obsolete, but are to be met with in old treatises. Occasionally rather more than a bare definition has been thought desirable. Acetabulum. Originally a vessel used by the Romans for holding vinegar at the table. Then a liquid measure about 2½ oz. Acetum Philosophicum. V

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Apothecaries’ Weights and Measures Signs.

It is not possible to ascertain with certainty the origin of the familiar signs ℈, ʒ, ℥, used in formulas and prescriptions to represent the scruple, drachm, and ounce respectively. A few guesses may be quoted, but actual historic evidence is not available. Dr. C. Rice, New York, an accomplished scholar and pharmaceutical authority, supposed that the scruple sign was a slightly modified form of the Greek gamma, γ, the first letter of “gramma,” the nearest Greek equivalent weight, and the origina

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℞

Paris, in “Pharmacologia,” pages 13 and 14, makes the statement that “such was the supposed importance of planetary influence that it was usual to prefix a symbol of the planet under whose reign the ingredients were to be collected; and it is not perhaps generally known that the character which we at this day place at the head of our prescriptions, and which is understood and supposed to mean Recipe, is a relict of the astrological symbol of Jupiter.” I have not met with that statement in any ea

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Planets and Metals.

There are no historic records of the origin of the association of the seven metals with the seven planets nor of the connection of either with the deities of antiquity. That Greece transmitted the mythological connection to Rome is clear enough, but it is not so certain whence Greece obtained the idea. Traces of it can be discovered in both Persia and Egypt, and it is not unreasonable to suppose that the circle of imagery may have developed from the worship of the sun. Allowing that heavenly bod

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Interpreting the Signs.

Interpretations of these symbols have often been attempted, but they are for the most part mere guesses. Those representing the sun and moon are easy, but the others may generally be read in various ways. The sign for Jupiter is alleged to represent one of his thunderbolts; that for copper is supposed to illustrate the looking-glass of Venus; the iron sign is the shield and spear of Mars; the caduceus of Mercury and the scythe of Saturn are likewise traced in their respective signatures. It has

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